The Citizens got off to the best possible start as they took the lead after only 90 seconds, as Leroy Sane tapped home after a horrendous error by Jean Michael Seri.
The game seemed to be going easily for City as they eased to a two goal lead just before half time, as David Silva scored his 50th Premier League goal for the reigning champions.
Fulham began the second half just like the first and found themselves three goals down only 90 seconds after the restart when Raheem Sterling tapped home from close range.
It was very much a routine victory for the home side, however, as always there were a number of big talking points from the game, so here are four things we learned from Saturday's clash.
4. The Etihad Is a Fortress
Man City's win over Fulham was their 18th win from their last 20 Premier League games, a truly astonishing feat.
The defeat to Manchester United back in April of last season was an obvious blip, however, since the arrival of Pep Guardiola his side have been incredible at home.
Not only are they devastating going forward, but at the back they are rock solid conceding only nine goals from 12 games in the league at home since the start of the year.
3. City Can Cope Even Without Kevin De Bruyne
The absence of star man Kevin De Bruyne is obviously a massive blow to the Citizens, however, after the team's display against Fulham it seems as though they can cope without their talisman.
Players like Bernardo and David Silva have proven that they can fill in during De Bruyne's absence, and will be crucial in chipping in with the assists and goals that De Bruyne normally provides.
2. Bernardo Silva Is an Incredible Talent
Bernardo Silva's first half display against Fulham on Saturday can only be described as majestic.
Silva ran the game for the Citizens and at times showed glimpses of truly incredible skill.
The Portuguese international was played out wide for the large part of last season, however, due to the absence of Kevin De Bruyne, Silva has been pushed into the middle of the pitch and its fair to say that since then the Portugal international has been brilliant.
It will be interesting to see what happens to Silva when his Belgian teammate returns, however, for the time being he is enjoying playing a star role in the heart of City's midfield.
1. Fulham Have the Quality to Avoid Relegation
It was a horrendous start for Fulham on Saturday and they never truly recovered from the early setback, however, small glimpses throughout the game showed that they contain the quality to remain in the top division.
The Cottagers went to the Etihad and played their normal passing game, and in at times they even managed to impress.
Unfortunately for Fulham they were undone by the quality of the home side and their own mistakes, however, going off of their previous performances in the league and minor moments of quality against City, it is likely that the Londoners will manage to avoid relegation this season.