Coincidentally, this fixture was the last top flight game involving the Cottagers before their relegation four years ago, so they will be looking to announce themselves on their return to England's top table.
Both sides possess a wealth of talent, with many individual battles looking likely to prove decisive on the outcome of the game.
Having said that, we've decided to narrow these battles down to just four, so let's take a look at some key match ups which may go some way to deciding the result:
1. Ryan Sessegnon vs. Aaron Wan-Bissaka
With just two years between them, 18-year-old Ryan Sessegnon and 20-year-old Aaron Wan-Bissaka's match up down the left hand side should be an intriguing watch.
Sessegnon, one of the country's brightest talents if not the best, has developed himself into a goalscoring threat on the left of midfield having originally began his career as a left back.
Wan-Bissaka, on the other hand, played his youth football on the right wing, but has developed into a right back at senior level, quite impressively it must be said.
Whoever wins this battle down the left could win the game for their team.
2. Jean Michael Seri vs. Luka Milivojevic
Fulham new boy Jean Michael Seri, signed from Nice for around £25m, looks to be a real coup for the newly promoted side. The Ivory Coast international developed a reputation as a lively box to box midfielder in France, scoring goals and assisting them, as well as maintaining his defensive duties.
His diminutive frame allows him to carry the ball effectively as he looks to make things tick in midfield. However, Palace's Serbian stalwart Luka Milivojevic will definitely make it hard for the 27-year-old Ivorian on what will be his Premier League debut.
Milivojevic enjoys dominating the midfield with his aerial ability and composure on the ball, the former of which Seri does not possess. Whoever wins the battle in the middle of the park will surely allow their flair players to do the business up top, which could be decisive on the result.
3. Wilfried Zaha vs. Calum Chambers
If there's a key battle on the pitch, Wilfried Zaha is certain to be involved in it. The talismanic Ivorian forward has moved into a more central role in recent times, meaning he will be up against one of Fulham's centre backs.
In this case, with Arsenal loanee Calum Chambers set to make his debut for Fulham, the pair's match up could prove vital in the outcome of the game.
Zaha usually ends up victorious in any battle he has with a defender, but with Chambers being a good player in his own right and eager to impress his new fans, an enticing watch between the pair could be on.
4. Aleksander Mitrovic vs. James Tomkins & Mamadou Sakho
The Serbian forward has made a permanent switch to the Cottagers having excelled for them on loan last season, his goals being the main reason that promotion was earned.
His physicality is an issue for any defenders, with his strong hold up play a vital factor in bringing Fulham's flair players into the game.
However, the partnership of Sakho and Tomkins is yet to taste defeat together in red and blue. Could the former Newcastle forward help his new side become the first team to beat the duo?