Ahead of what is expected to be a fiercely contested fixture on Wednesday, Manchester City have already secured top spot in this Champions league group campaign. However, after a 3-0 loss against Napoli, Shakhtar Donetsk are just three points ahead of the Italian side; with an inferior goal difference.
Napoli are expected to beat Feyenoord in the other Group F game meaning Shakhtar need at least a point to secure qualification.
Thanks to a late David Silva goal at the weekend, Manchester City have equalled the Premier League record of 13 consecutive wins and also surpassed the previously held record by Guardiola's 2013/14 Bayern Munich team; of 19 wins in all competitions across Europe's top five leagues.
Ever the perfectionist, Guardiola is determined to win this fixture and despite the pressure of the Manchester Derby will not play a weakened side. Here's who could feature.
While Bravo could be in line for a start, consistency in defence is vital for the games ahead.
After being rested at the weekend, Vincent Kompany is in line for a return to the starting lineup and will likely be joined by Otamendi. The Argentine is in incredible form, scoring four goals this season; including one at the weekend.
Danilo was sacrificed at half time in mid-week, but is expected to regain his place with Kyle Walker maintained at right back.
With Kevin De Bruyne suspended and David Silva left out of the squad with a mild injury, it will be changes all round in midfield.
Due to Shakhtar Donetsk's fast starting approach, Guardiola is likely to begin with a cautious line up featuring Toure and Gündogan, who were both left out of the previous fixture. While Fernandinho is also likely to feature against his former side.
Phil Foden and Brahim Diaz have both travelled with the squad and could be in line to feature.
- Leroy Sane19
Gabriel Jesus provided the crucial assist to Otamendi's opening goal against West Ham and will likely be rewarded with a starting position in this fixture.
Introduced as a late substitute in the previous fixture, Bernardo Silva is also expected to start ahead of Raheem Sterling; who is certain to start at the weekend.
The Portuguese winger has struggled for game time in the premier league, but has had much more success in the Champions league and equals his fellow winger's statistics of 1.4 key passes per game.
Leroy Sane could round off the front three with two assists in his last champions league away fixture. All three will be looking to stake their claim for a starting place at the weekend.